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Subjects from the placebo group did not show differences in total glutathione levels when comparing start with end of the study (medians, V2 = 824.4, V4 = 780 mg/L per % Ht, p -value = 0.734) (Figure 4B)

Loss of GSH synthesis induces transcription of NRF2 target genes and repression of lipogenic genes GSH synthesis is required for numerous enzymatic processes across a range of cell types in the body

Trade-offs: Can cause morning grogginess, orthostatic hypotension, or REM alterations

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