The region of the H-NMR spectrum related to the N-acetyl groups (2.151.90 ppm) was deconvoluted using three Lorentzian functions in order to calculate the specific concentrations of N-acetylglucosamine and N-acetyl galactosamine (GlycA) and N-acetylneuraminic acid (GlycB) [37]
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This is important not only because GLP-1 receptor agonists have become very popular as pharmaceutical drugs to treat diabetes and obesity (JY Wang et al.), but also because, as we will see later, GLP-1 prevents amyloidosis of the amyloidogenic small peptide hormone amylin, which is normally released along with insulin from the pancreatic -cells when blood sugar levels are elevated
