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10.1172/JCI154225 9

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it may prevent the use of systemic antibiotics and thereby prevent antimicrobial resistance and improves patient compliance/adherence to the therapy and, most importantly, compared to systemic therapy, the risk of medication toxicity is significantly lower

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In general, tetracycline drugs are not used simultaneously, indicating that this method has acceptable specificity

These include iron metabolism, the System Xc-/GSH/GPX4 antioxidant pathway, and lipid peroxidation processes