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While these findings are promising, the complexity of human neurodegenerative diseases and the limitations of animal models necessitate cautious interpretation pending clinical validation

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[38] The final results of the TACT trial were published in November 2012

A substantial body of clinical evidence accumulated over the past two decades, consistently demonstrates that NSW is able to significantly suppress endogenous melatonin secretion, as measured through urinary and salivary metabolites, primarily aMT6s and 6-hydroxymelatonin sulfate (6-OHMS) 171

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