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Despite low CNS penetration, some studies report detectable levels in the brain, supporting its potential for systemic biological effects without significant accumulation (Jzwiak et al
Similar results were obtained with erastin-2 or RSL3, two well-known inducers of ferroptosis, while treatment with fer-1 significantly reduced lipid peroxidation, indicating that ferroptosis was implicated in this PA-induced process (Fig
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A hypoxic microenvironment, which is a hallmark feature of GBM, influences MMP regulation
The supernatant was collected by centrifugation (10 min, 12,000 g , 4C) and frozen at 20C until analysis via HPLC
While glutathione is naturally present in the body, the implications of supplementation are still being studied
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