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For example, the MEK inhibitor trametinib combined with 5-FU has been shown to synergistically suppress the MAPK pathway and enhance the response to neoadjuvant chemoradiotherapy [156]

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Elamipretide selectively accumulates within the inner mitochondrial membrane, where it exerts its cytoprotective effects

Yang et al., 2025

In addition, integrative approachessuch as combining probiotics with digital healthsupported managementmay enhance broader outcomes, including nutritional status, systemic inflammation, and quality of life (Ou et al., 2021

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