There are no known contraindications
This process might be regulated by reactive oxygen species (ROS) generated in mitochondria ( Lipids required for ATG8 lipidation and membrane extension are delivered to the phagophore via ATG2 and ATG9, where ATG9 acts as a seed to initiate lipid transfer by ATG2 that acts as a hose funneling lipids from relevant compartments (e.g., the ER) to the phagophore ( Figure 1 , panel 3)
, Clifford, M
But too much can be a problem
288 Existing studies have demonstrated that L-DON and JHU-083 can extensively inhibit Gln metabolizing enzymes and activate AMPK and c-Myc to inhibit glycolysis, thereby stopping tumor metabolic activity, alleviating hypoxia, and increasing the concentration of Gln and glucose in TME
Lykke et al., 2015), which are unevenly distributed throughout tissues (Zhang et al., 2023)