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Excessive ROS can oxidatively modify KEAP1, leading to its separation from NRF2, activating the expression of antioxidant genes
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Fourthly, the severity of the IVD degeneration possibly influences the therapeutic effect of injected cells and/or growth factors, since degenerated CLCs may have lost their chondrogenic potential and the effect of injected cells and/or growth factors may differ between early and severely degenerated IVDs [90]
(2004) www.sciencedaily.com From the article: Our findings suggest that it might be important for women taking estrogen after menopause to also take androgen supplements which can include testosterone, [] Half of the monkeys were given oral contraceptives, which contain estrogen, in their diets for 26 months