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The global societal burden is equally significant, with total direct and indirect costs estimated to exceed $112 billion USD annually by 2023 (Ola et al., 2022

CFTR participates in spermatogenesis, and evidence suggests its involvement in seminiferous intratubular fluid control, maintenance of the bloodtestis barrier, and improvement in follicle-stimulating hormone signalling, among other functions

Also, reduced glutathione is more sensitive to environmental conditions , so its preservation requires specific processes to prevent degradation

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The lower the glutathione level, the greater the likelihood of cellular deterioration, disease risk and cellular death

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