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employed in osteoarthritis and cartilage regeneration research Pigs Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys 9-month chronic toxicology studies via oral gavage Human subjects Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development

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Actin is a protein that allows cells to move

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Lyophilisation (freeze-drying) removes water, halting hydrolysis entirely

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If the muscle actually tenses during the injection, that can create more damage, inflammation and discomfort, says Dr

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