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This work was funded by the European Regional Development Fund (FEDER), through the Competitiveness Internationalization Operational Programme (POCI), and by national funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-0 31987

Human clinical data limited to case reports and small trials, not large controlled studies

These results indicated that the disturbed profile of plasma metabolites was strongly associated with the altered concentrations of cytokines and chemokines, implying that altered metabolic profiles might affect the pathogenesis of MS by modulating the immuno-inflammatory responses in the peripheral system

This is achieved through several mechanisms, such as mitochondrial biogenesis and adaptive thermogenesis

Moreover, petrelintide studies NCT06662539 and NCT06926842

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