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Also, IGF-1 can suppress various proapoptotic signals through regulation of multiple downstream targets [55]

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TH signaling and ocular tumors TH signaling and retinoblastoma Retinoblastoma (Rb) is a rare pediatric intraocular malignancy that originates in the developing retina and is driven by biallelic inactivation of the RB1 gene [305,306,307]

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