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Interestingly Th2 cytokines like IL-4, IL-6 and IL-10 remained unchanged [318]

This approach allows for early safety evaluation before broader cohort exposure

However, the significance of this effect is unclear as the authors did not include comparator groups without dextran sulfate sodium treatment, which would be needed meaningfully assess the effect of the treatment on circadian rhythmicity

Over time, as telomeres continue to shorten, cells may lose their ability to divide normally and can enter a state known as cellular senescence

doi: 10.26355/eurrev_202012_24046