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While findings remain varied, DSIP continues to be of interest for its role in neuroendocrine regulation

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1992 May 15;89(10):4678-82

THP-1 cells were seeded at 2 10 5 cells per well in complete RPMI 1640 medium with 100 nM phorbol 12-myristate 13-acetate (PMA) (Cayman) and differentiated into macrophages for 3 days, then rested in PMA-free medium for 16 h before infection

In clinical trials, participants lost between 5% and 15% of body weight, especially when combined with semaglutide

Mechanistic gaps: The exact molecular pathways in human adipocytes remain under investigation