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Organic oxidants promote mitochondrial lipid peroxidation and ROS accumulation tBHP also induced lipid peroxidation in the mitochondrial fraction as assessed by a mitochondria-targeted fluorescent sensor mitoPeDPP (Fig
News, Medical and Life Sciences, Obesity drug codenamed AOD 9604 highly successful in trials, 16 December 2004, Kwon DR, Park GY
Thereby, PI3K and AKT transcription was downregulated 1.7- and 2-fold, respectively, whereas PGC-1 transcripts were increased 7-fold and AKT phosphorylation was reduced by 3550%
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Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling
