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3.2 Preclinical studies of ferroptosis in neurodegenerative diseases 3.2.1 Ferroptosis and alzheimers disease AD is a prevalent and progressive neurodegenerative disorder, characterized by the accumulation of extracellular -amyloid (A) plaques and intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein, accompanied by excessive neuroinflammation, synaptic dysfunction, and neuronal loss, ultimately resulting in impairments in language, judgment, and executive function, and even leading to the loss of independent living ability (Hooper et al., 2025)
8 , eadd6910 (2023)
J Clin Psychiatry 70(6):919921
Accordingly, conclusions should be interpreted as an evidence map and perioperative risk framework rather than confirmation of clinical efficacy or safety