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During local inflammation occurs the synthesis and release of molecules such as monocyte chemotactic protein (MCP)-1, chemokine derived from macrophage (MDC), tumour necrosis factor (TNF)-, interleukin (IL)-8, vascular endothelial growth factor (VEGF), leukaemia inhibitory factor (LIF), fractalkine, and urokinase plasminogen activator (uPA) [53, 61]

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