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These LL-37/DNA complexes are potent activators of plasmacytoid dendritic cells, triggering massive production of type I interferons, the same cytokines that drive the "interferon signature" characteristic of active lupus

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Hepatic fibrosis, a dynamic and potentially reversible process, arises from chronic liver injury where immune cells and hepatic stellate cells drive excessive extracellular matrix deposition

The ability of NRF2 to regulate xCT coupled with the decline of NRF2 with age 178 might account for the increased levels of plasma cystine seen with increasing age