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10.1016/j.fmre.2023.08.011 57 WangX.LiM.DiaoK.WangY.ChenH.ZhaoZ.et al (2023b)

Protocol 1: pain-dominant fibromyalgia (beginner) Goal: Address widespread pain and inflammation as primary symptoms Peptides: BPC-157 : 500mcg twice daily subcutaneous Duration: 8-12 weeks initial protocol Why this works: BPC-157 provides broad anti-inflammatory and healing effects with an excellent safety profile

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In this study, we demonstrated that GSSG accumulation induced by either H 2 O 2 exposure or GR inhibition suppressed TNF-induced NF-B activation

Taking evidence in account, more studies are necessary to go deep into the participation of oxidative stress, mitochondrial dysfunction and inflammatory response in the development of PDN