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Endothelial cells comprise the inner monolayer of blood vessels that forms a barrier between the artery wall and circulating blood is responsible for regulating vascular tone, regulation of hemostatic properties on the vascular surface, and determining blood-tissue/brain permeability (Paschos and FitzGerald, 2010)

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So, when does it make sense to bring out the big guns

Blended products simplify administration but reduce transparency and flexibility in research design