It further shows that the levels of ATF4 and GSH in several human CML blast-crisis cell lines are inversely correlated with JMF4073 sensitivity, and the combinatory treatment of JMF4073 with GSH reducing agent leads to synthetic lethality in these CML blast-crisis lines
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The MR-Egger intercept method identified horizontal pleiotropy between serum Ca levels and GD (MR-Egger intercept = 0.010, p = 0.030), with no similar findings for other micronutrients
Also, an activation mechanism involving an attack of H 2 S/HS at a disulfide in the intracellular kinase core was postulated for EGFR regulation ( + /K + -ATPase endocytosis in renal tubular epithelial cells through a downstream signaling pathway