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Generally, the induction of the type I IFN response targets different immune cells from antigen-presenting dendritic cells, T cells to natural killer (NK) cells (200)
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This association is further supported by recent findings suggesting that glutamine deprivation may enhance the CRC migration and invasion by inducing the epithelial-to-mesenchymal transition (EMT) process (61)
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However, bacterial genomic DNA was detected in multiple organs in TLR2 / TLR4 / mice, indicating intravascular dissemination from gingival tissue to the heart, aorta, kidney, and lungs
