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Higher energy collisional dissociation (HCD) fragmented (isolation width 1.2 m / z and 28% normalised collision energy) MS/MS scans in a cycle time of 1.1 s, the most abundant 25+ charged peaks in the MS scan were recorded in a data-dependent mode (Resolution 15,000, threshold 2e4, 15 s exclusion duration for the selected m / z 10 ppm)

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Future research involving case series could provide more comprehensive insights

Their study illustrates the critical importance of modeling nanoparticle biological interactions such as cellular uptake, immune evasion, and in vivo degradation patterns early in the design phase

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