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RLS has been linked to genetic predispositions, iron deficiencies, and certain chronic conditions, such as diabetes or kidney disease

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doi: 10.2174/1871527320666210806165430

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The role of NADPH, the reduced form of nicotinamide adenine dinucleotide phosphate (NADP + ), in mediating inflammatory and anti-inflammatory responses in activated myeloid cells has been well-established in the past decades

In addition, the observed side-chain flexibility of V12 and F112 indicated that these residues are mainly involved in the overall shaping of the active site and help to position the flavonoid substrate in accordance with the presented structural evidence