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Furthermore, the levels of transcortin (or corticosteroid-binding globulin), the primary glucocorticoid-binding protein and a negative control protein, were substantially lower in IMDD patients than in controls [39]

The gut-brain axis is real, and gut inflammation does correlate with depression and anxiety

What underpins progression at the tissue, cellular and molecular levels is still unknown, but taken together, emerging data strongly point to an underlying chronic cytodegenerative process starting early and operating largely independently of overt inflammation

doi: 10.1007/s00726-011-1200-z SAUNDERS, B., DE SALLES PAINELLI, V., DE OLIVEIRA, L., DA EIRA SILVA, V., DA SILVA, R., & RIANI, L