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Protection of tissue structures under stress

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

Studies indicate a connection between stress and the health of stem cells in hair follicles, emphasizing the importance of stress management

SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

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