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The delivery system not only improves the water solubility and bioavailability of sorafenib, but also increases the accumulation of the drug in the tumor site through an active targeting mechanism, thereby maintaining efficacy at lower doses and reducing toxic reactions (Table 2)

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Can be diluted in a glass of water or juice

Cys 2 ), cystine-free (Cys 2 -free), or cystine-free/GSH-supplemented (750 M) medium for the indicated timepoints, and cell numbers were determined (n = 2 technical replicates representative of one experiment)

10.1016/j.jinf.2021.05.004 93 KrechJ.TongG.WowroS.WalkerC.RosenthalL

Tie-2 is the tyrosine kinase receptor for Ang-1 and Ang-2, molecules that regulate angiogenesis and endothelial cell survival, proliferation and migration (73)