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Exercise, as a critical adjunct to pharmacological therapy, has been extensively shown to confer multiple therapeutic benefits in NDDs, including suppression of neuronal ferroptosis, mitigation of neuroinflammation, reduction of Tau hyperphosphorylation, and enhancement of cognitive performance (Gutierre et al., 2025)

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Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains