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doi:10.1016/j.jocn.2021.11.029

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Dose-Response Evidence from Preclinical Gastroparesis Models The clearest dose-response data comes from induced gastroparesis models using either cysteamine (which causes duodenal ulcers that impair pyloric function) or L-NAME (a nitric oxide synthase inhibitor that paradoxically causes delayed emptying through vascular dysfunction)

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Moreover, a slight reduction in the inhibitory ability was observed when residue M44 was substituted with alanine