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This is consistent with previous findings that fibrosis may accelerate -cell destruction or induce the destruction of -cell connectivity, leading to decreased insulin secretion [23, 32]

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Single-point energies were calculated on the optimized geometries using the B97X-D hybrid functional 87 and the 6-311 + G(2d,p) basis set with ultrafine integration grids for the QM part and the ff14SB, gaff2 and TIP3P force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

doi: 10.1007/s001250050604 12 HedmanCAFrystykJLindstromTOskarssonPArnqvistHJ