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Figure 7, taken from an in vitro and ex vivo study assessing synbiotic combinations, shows for example significant differences in the abundance of specific bacterial groups such as Bifidobacteria and Lactobacilli in response to synbiotic treatments compared with probiotics or prebiotics alone [130]

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In metastatic pancreatic cancer patients treated with ganitumab and gemcitabine, higher circulating levels of IGF-1, IGF-2 or IGFBP-3 was associated with better response in Phase II trials [100], but stratifying patients based on these biomarkers did not translate into survival benefit in Phase III trials [52]

Many transporters are involved in maintaining carnitine homeostasis