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318,319,320 It implies that lactate metabolism reprogramming towards T cells may be a double-edged sword which elicits a sophisticated effect on its antitumor immunity, which waits to be further investigated

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For instance, GM dysbiosis driven by estrogen deficiency may predominantly exert its effects through modulating systemic inflammation and immune cell activity, whereas in age-related OP, GM alterations is often associated with several other age-related diseases, such as sarcopenia, nutritional malabsorption

Zhou JF, Wang XY, Shangguan XJ, Gao ZM, Zhang SM, Xiao WQ, Chen CG: Increase oxidative stress in women with pregnancy-induced hypertension

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The immunologic theory of aging