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(6) Multifactorial Interventions: neurodegenerative diseases are often complex conditions that may require multimodal treatments

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Only one application is needed per day, as the nutrients have a long half-life.

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While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20