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These studies often investigate how actin-regulating peptides influence fibroblast movement, endothelial cell behavior, and the coordinated activity of immune and connective tissue cells within injury models

We strongly recommend it, but no - you do not have to have one if you choose not to, though we do explain why this is storngly recommended

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EMBO J (2001) 20(23):657082

Similarly, in models of 6-OHDA-induced or spontaneous cell death, UA pretreatment prevented the activation of ROS-related death pathways and increased cell viability [169, 170]