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However, during apoptosis, the mitochondrial membrane potential is lost and the mitochondrial permeability transition pore (MPTP) remains open, allowing TMRE to escape into the cytoplasm, resulting in a significant reduction of orange-red fluorescence within the mitochondria [44]

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Researchers could not identify either a minimum toxic dose or a lethal dose despite testing across a three-thousand-fold range of exposures

Antihyperglycemic activity of trigonelline and sitagliptin in nicotinamide-streptozotocin induced diabetes in wistar rats

These cells were then exposed to various stress-inducing agents, including menadione to induce oxidative stress, blue light, and pollutants, mimicking real-world environmental challenges