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These enzymes control the methylation cycle speed and efficiency, determine homocysteine levels, and indirectly affect glutathione production

Figure 2 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 3) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors

Well-designed clinical trials in humans are needed

10.1016/j.beem.2012.05.002 Best Pract