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K560, a HDAC 1 and 2 isoform specific inhibitor, attenuated MPTP induced cell death in SH-SY5Y cells in vitro and prevented MPTP-induced loss of dopaminergic neurons in substantia nigra in mice in vivo (Pinho et al., 2016)

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These supportive measures complement rather than replace peptide therapy

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408 Two populationbased studies found higher rates of cognitive impairment among SGM older adults than among nonSGM older adults, 409 , 410 although a third study reported that the risks for dementia and mild cognitive impairment were similar for people in samesex relationships and people in anothersex relationships