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Some studies indicated that maintaining a high level of GSH or GSH/GSSG is important for the response to different stresses, such as drought tolerance in mung bean 26 , low temperature tolerance in loquat 27 , and isoproturon toxicity in wheat 28

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One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)