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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

Imai and colleagues aim to clarify the critical inter-tissue communications among the hypothalamus, skeletal muscle, and adipose tissue in governing mammalian aging and lifespan

Transected muscle had accelerated muscle fiber regeneration and improved restoration of muscle force

Reference sources: Sigma-Aldrich 5-Amino-1MQ (SML2832) | NIH PMC NNMT Inhibitor Research Regulatory Notice 5-Amino-1MQ is an unapproved new drug compound

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Angiogenic potential of skeletal muscle derived extracellular vesicles differs between oxidative and glycolytic muscle tissue in mice