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These findings suggest a potential therapeutic ceiling when combining agents with overlapping mechanismsincluding natriuresis, afferent arteriolar constriction, and anti-inflammatory effectsand underscore the need for further investigation into optimal sequencing and drug combinations

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Ekdahl CT, Claasen JH, Bonde S, Kokaia Z, Lindvall O

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Biomaterials 16:905910 Waters RV, Gamradt SC, Asnis P, Vickery BH, Avnur Z, Hill E, Bostrom M (2000) Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model