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They help regulate numerous biological processes, including hormone production, tissue repair, metabolism, immune function, and collagen synthesis

Oxidative stress biomarkers (8-isoprostane) decreased by 35%

Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing

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Research has examined its role in sleep regulation, stress modulation and neuroendocrine activity, including effects on circadian rhythm and interactions with the hypothalamic-pituitary axis