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Hypoxia-induced mROS inhibits HIF-1 hydroxylation and upregulates the HIF-1/PDK1&PDK2/p-PDH-E1 axis, enhancing lactate production and histone lactylation

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Indeed, GLS inhibitors have shown promising tumor-suppressive activities in preclinical models for 968 and bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), or even in clinical models for CB-839 [100,101]

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