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The use of small molecules that alter the levels of ROS such as -phenethyl isothiocyanate (PEITC), buthionine sulphoximine, curcumin, or 2-cyano-3,12-dioxooleana-1,9-diene-28-oic acid (CDDO) derivatives, has been suggested for the treatment of cancer by promoting ROS generation and GSH depletion in cancer cells (Schumacker, 2006

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