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Patient-centred strategies must identify patients tumour, current and planned conventional therapies (chemotherapy, endocrine therapy, targeted therapy and immunotherapy), comorbidities, organ function, nutrition profile, dietary habits and existing medication or supplement use since these factors critically impact both the efficacy and safety of supplementary approaches (236)

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Ang II was previously discovered as a pro-hypertensive factor present in areas of the brain associated with cardiovascular and has recently been found to be associated with motor activity, anxiety, learning, and memory (28, 42)

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In vivo assays assess the real-world effectiveness of antioxidants by measuring oxidative stress biomarkers and related health outcomes across tissues and organs (Sacchet et al., 2015)