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Selective VEGFR-2 inhibitors: synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling

Novel, potent and selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities

, 44 , 771-786, doi: Schwarzer, R., Laurien, L., and Pasparakis, M

L., Synthesis and StructureActivity Relationship Analysis of 2Substituted1,2,4Triazolo[1,5a]Pyrimidin7Ones and Their 6Carboxylate Derivatives as Xanthine Oxidase Inhibitors, ChemMedChem 20 (2025): e202400598, 10.1002/cmdc.202400598

The remarkable diversity of inhibitory neurons and plasticity mechanisms they express might impose additional constraints on the homeostatic mechanisms

The main risks are skin irritation with high concentrations and the contamination concerns associated with poorly sourced or improperly prepared formulations