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The other mimics gut hormones that control hunger and insulin

Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (41, 62, 63)

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This provides proof-of-concept that combining system x C inhibitors with APR-246 is clinically translatable and may potentially have significant therapeutic efficacy against mut-p53 malignancies

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Glucose transporters such as GLUT1, GLUT3, GLUT4, GLUT8, SGLT1 and SGLT6 have been found to be expressed in various brain regions [60]