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They induce alterations in RAS expression in heart tissues, decreasing angiotensin II, the most powerful vasoconstrictor, in the tissues, responsible for hypertension and cardiac hypertrophy

Deeken CR, Chen DC, Lopez-Cano M, Martin DP, Badhwar A (2023) Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: a scoping review

So I think this gives people an idea of what can be done. The work also demonstrates the power of this relatively new computational technique, van de Walle says

Nonetheless, addressing macrophages specifically in various CL forms poses challenges, as lesions are often distal and deep-seated in the skin, making the delivery of therapeutic agents difficult, whether locally or systemically (144)

Its a factor of 1,000

C., Almeida, L