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Mukherjee K, Lee A, Zhu L, et al

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Secondary endpoints included changes from baseline in patient-reported outcomes related to body image, triglycerides, ratio of total cholesterol to HDL cholesterol, IGF-1 levels, and safety parameters

Through lipidation, a process where a fatty acid chain is attached to the peptide molecule, researchers gave cagrilintide a half-life long enough for once-weekly dosing

The peptide's biological activity depends entirely on maintaining the chelated copper ion in its Cu oxidation state, bound to the histidine and lysine residues through coordinate covalent bonds

References Thobde, A