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So, lets break it down in a way thats fun, educational, and easy to understand

10.1530/REP-17-0530 9 ChenJ.SaggarJ

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(16) Diving deeper, the team sought to unravel the effects of this compound on the contractile dynamics of gastric smooth muscles when exposed to acetylcholine and electrical field stimulation

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This theory is that free radicals, as by-products of mitochondrial oxidative metabolism, cause cumulative cellular damage that results in overall loss of organismal fitness over time