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272 P2Y1R is a receptor that is preferentially activated by ADP and is significantly upregulated in the colonic epithelial cells of UC patients

J Am Soc Nephrol 7:710720 Friedlaender M, Popovtzer MM, Weiss O, Nefesh I, Kopolovic J, Raz I (1995) Insulin-like growth factor-1 (IGF-1) enhances recovery from HgCl2-induced acute renal failure: the effects on renal IGF-1, IGF-1 receptor, and IGF-binding protein-1 mRNA

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It was unregulated access without physician oversight, and that risk doesnt go away no matter what the regulatory status becomes